Cell death
Dysregulation of the cell death pathways has been attributed to several diseases and disorders such as cancer, autoimmune diseases, and neurodegenerative disorders. Determining the type of cell death is crucial for understanding the cell death mechanism and thus for the planning of therapeutic approaches and drug designing.
Different cell death modalities are characterized by their specific sequential morphological patterns.
Q-Phase detects the quantitative values of cell dry mass and morphological changes of each cell across time, thus providing a rapid and label-free method for the prediction of the provisional type of cell death.
Moreover, Q-Phase constitutes a comprehensive tool that merges both QPI and fluorescence which allows for studying the time-dependent morphological changes simultaneously with the concomitant biochemical markers.
Dynamic visualization of different steps of the process of cell division through super-resolution LiveCodim imaging could bring new insights into the understanding of the mechanism involved in this process, for example by visualizing microtubule functioning during mitosis.
Publications
Coherence-controlled holographic microscopy enabled recognition of necrosis as the mechanism of cancer cells death after exposure to cytopathic turbid emulsion
Multimodal Holographic Microscopy: Distinction between Apoptosis and Oncosis
The Quantitative-Phase Dynamics of Apoptosis and Lytic Cell Death
Quantitative Phase Dynamics of Cancer Cell Populations Affected by Blue Light
Products
Telight Q-Phase
Quantitative Phase Imaging
Q-Phase is a patented holographic microscope with high detection sensitivity.
Q-Phase is an ideal solution for experts who desire precise automated segmentation of individual cells for subsequent data analysis. Q-Phase quickly transforms cell features and dynamics into numerical data suitable for comparisons, correlations, and more detailed statistics.
Telight LiveCodim
From conventional to super-resolution microscopy
LiveCodim is the universal 3-in-1 imaging platform for wide-field, confocal and super resolution microscopy. It is designed to interface with any standard fluorescence microscope and is the solution for live cell imaging with high resolution and low phototoxicity.